The transfectability and cell motility on materials with different physico-chemical properties

Abstract

Gene delivery by non-viral vectors is limited by cytotoxicity. In this study, we transferred plasmid DNA into stem cells by seeding cells on substrates with different physicochemical properties. Gene entry was facilitated by the activation of integrins and cell motility on different material surface. The finding could be used to screen materials that promote cell migration and endocytosis.