Effects of Justicia acuminatissima, or Amazonian Sara Tudo, on ischemic acute kidney injury: An experimental study

Abstract

Objective: To evaluate the effects of Justicia acuminatissima, or Amazonian Sara Tudo, on renal hemodynamics, oxidative profile, and renal histology in rats with ischemic acute kidney injury. Method: Preclinical assay with adult male Wistar rats, weighing from 250 g to 350 g, distributed into Sham, ischemia, and ischemia + Sara Tudo groups. Hemodynamic parameters, renal function, oxidative stress, and renal histology were evaluated. Results: Pretreatment with Sara Tudo reduced the functional injury, which was shown by the increase in creatinine clearance and thiols; reduction of oxidative markers, renal vascular resistance, and tubulointerstitial injury in the renal tissue; and the significant improvement in renal blood flow. Conclusion: The renoprotection provided by Justicia acuminatissima, or Sara Tudo, in cases of ischemic acute kidney injury was characterized by a marked improvement in renal function, reducing the oxidative injury, and impacting on renal histology positively.