Dietary effect of a live-bacterial drug on lipid metabolism and immune function of sprague-dawley rats

Abstract

The live-bacterial drug use here is a medicine for intestinal disorders containing 3 bacteria, Streptococcus faecalis T-110, Clostridium butyricum TO-A and Bacillus mesentericus TO-A. Male Sprague-Dawley rats were fed the drug for 3 weeks to examine its dietary effect on their lipid metabolism and immune function. In lipid metabolism, we found that serum triglyceride level was significantly low in the rats fed the drug. In immune function, serum immunoglobulin (Ig) levels and Ig productivity of spleen lymphocyte were not affected by the drug feeding. On the other hand, Ig productivity of mesenteric lymph node was significantly affected by the drug feeding, but the IgA level in the feces of the rats was significant decreased. These results suggest that the live-bacterial drug modulates lipid metabolism and gut immune system of rats.