Metabolic syndrome and gout

Abstract

The association between gout and the phenotype that we now recognize as metabolic syndrome has been recognized for thousands of years. With aging population, increasing prevalence of risk factors for metabolic syndrome, the number of people in the general population with metabolic syndrome and gout is large and is rising over time. This chapter summarizes contemporary literature on this topic as well as provides the latest data on the incidence and prevalence of metabolic syndrome in gout in the US. The potential pathophysiological links between metabolic syndrome and gout such as oxidative stress, and inflammation is discussed in the context of the epidemiologic data.