Designing an effective nanoparticle for selective drug transport requires careful consideration of the complex biological barriers encountered in transit to the desired target. Here, we review several of these barriers, and provide possible methods for formulating liposomal nanoparticles to overcome them. The methods include the biotinylation of an antibody, and subsequent conjugation to a PEGylated cationic lipid nanoparticle. Additionally, the incorporation of drug, and other relevant characteristics of the nanoparticle are also discussed.
CITATION STYLE
Richards, S. M., & Campbell, R. B. (2017). Piloting your nanovehicle to overcome biological barriers. In Methods in Molecular Biology (Vol. 1530, pp. 139–145). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6646-2_9
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