Interactions of Benzodiazepines with Warfarin

Abstract

Administration of nitrazepam (10 mg nightly), diazepam (15 mg/day), and chlordiazepoxide (15 and 30 mg/day) had no effect on steady-state plasma warfarin concentrations, the plasma half-life of warfarin, or anticoagulant control in patients and it appears safe to prescribe these agents to patients on long-term oral anticoagulants. Urinary excretion of 6 (3-hydroxycortisol, however, increased in two out of five patients given chlordiazepoxide. In rats. © 1972, British Medical Journal Publishing Group. All rights reserved.