Molecular characterization of Acanthamoeba isolated from amebic keratitis related to orthokeratology lens overnight wear.

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Abstract

In an effort to characterize, on the molecular scale, the Acanthamoeba initially isolated from the cornea of an amoebic keratitis patient associated with overnight-wear orthokeratology lens in Korea, we conducted mitochondrial DNA restriction fragment length polymorphism, 18S rDNA sequencing, and drug sensitivity analyses on the isolate (KA/PE1). The patient was treated with polyhexamethylene biguanide, chlorhexidine and oral itraconazole, which resulted in resolution of the patientos ocular inflammation. The majority of the molecular characteristics of the KA/PE1 were determined to be identical, or quite similar, to those of A. castellanii Ma strain, which had been isolated also from amoebic keratitis. The risk of Acanthamoeba keratitis as a potential complication of overnight orthokeratology is briefly discussed.

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Lee, S. J., Jeong, H. J., Lee, J. E., Lee, J. S., Xuan, Y. H., Kong, H. H., … Yu, H. S. (2006). Molecular characterization of Acanthamoeba isolated from amebic keratitis related to orthokeratology lens overnight wear. The Korean Journal of Parasitology, 44(4), 313–320. https://doi.org/10.3347/kjp.2006.44.4.313

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