IkB kinase β (IKKβ) inhibits p63 Isoform γ (TAp63γ) transcriptional activity

Abstract

Background: The functional regulation of p63 Isoform γ (TAp63γ) by IkB Kinase β (IKKβ) remains unknown, although they were previously shown to bind to each other. Results: IKKβ, but not its kinase dead mutant, suppressed the transcriptional activity of TAp63γ by disrupting its interaction with p300. Conclusion: IKKβ negatively regulates the transcriptional activity of TAp63γ. Significance: IKKβ may favor cell proliferation by inhibiting TAp63γ activity. © 2013 by The American Society.