Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease

44Citations
Citations of this article
50Readers
Mendeley users who have this article in their library.

Abstract

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that regulates organ size control, plays an important role in governing ovarian physiology, fertility, and pathology. Specific to the ovary, the spatiotemporal expression of the major components of the Hippo signaling cascade are observed throughout the reproductive lifespan. Observations from multiple species begin to elucidate the functional diversity and molecular mechanisms of Hippo signaling in the ovary in addition to the identification of interactions with other signaling pathways and responses to various external stimuli. Hippo pathway components play important roles in follicle growth and activation, as well as steroidogenesis, by regulating several key biological processes through mechanisms of cell proliferation, migration, differentiation, and cell fate determination. Given the importance of these processes, dysregulation of the Hippo pathway contributes to loss of follicular homeostasis and reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency, and ovarian cancers. This review highlights what is currently known about the Hippo pathway core components in ovarian physiology, including ovarian development, follicle development, and oocyte maturation, while identifying areas for future research to better understand Hippo signaling as a multifunctional pathway in reproductive health and biology.

References Powered by Scopus

Role of YAP/TAZ in mechanotransduction

4216Citations
N/AReaders
Get full text

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

2480Citations
N/AReaders
Get full text

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

1978Citations
N/AReaders
Get full text

Cited by Powered by Scopus

n-3 PUFA Promotes Ferroptosis in PCOS GCs by Inhibiting YAP1 through Activation of the Hippo Pathway

12Citations
N/AReaders
Get full text

FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells

11Citations
N/AReaders
Get full text

Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries

11Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Clark, K. L., George, J. W., Przygrodzka, E., Plewes, M. R., Hua, G., Wang, C., & Davis, J. S. (2022, December 1). Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease. Endocrine Reviews. Endocrine Society. https://doi.org/10.1210/endrev/bnac013

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 12

63%

Professor / Associate Prof. 3

16%

Researcher 3

16%

Lecturer / Post doc 1

5%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 10

56%

Nursing and Health Professions 3

17%

Medicine and Dentistry 3

17%

Agricultural and Biological Sciences 2

11%

Save time finding and organizing research with Mendeley

Sign up for free