Double-Blind Randomized Comparison of Carbetocin Versus Oxytocin for Decrease Blood Loss from Cesarean Section in Low-Risk Uterine Atony

Abstract

INTERVENTION: normal saline 5 ml with 100 microgram Carbetocin and physiological solution 1000 ml at an infusion rate of 120 ml/h, received normal saline 5 ml and physiological solution 1000 ml with oxytocin 20 unit at an infusion rate of 120 ml/h CONDITION: pregnant women with low‐risk uterine atony cesarean section pregnant women with low‐risk uterine atony cesarean section ; pregnant women with low‐risk uterine atony cesarean section PRIMARY OUTCOME: amount of blood loss from cesarean section in low‐risk uterine atony [Timeframe 24 hour after cesarean section blood that was sucked in operation and weighing sanitary napkin that used after cesarean section] SECONDARY OUTCOME: additional uterotonic use [Timeframe 24 hour after cesarean section number of case that add uterotonic drugs] Admission days [Timeframe admission to discharge from hospital number of days ] Blood transfusion [Timeframe 24 hour after cesarean section number of case that used blood transfusion] cost of hospitalization [Timeframe admission to discharge from hospital cost of hospitalization in Thai Bath] Hb, Hct level pre and post operative [Timeframe 24 hour after cesarean section CBC pre‐operative and CBC at 24 hour after cesarean section] side effect drugs [Timeframe admission to discharge from hospital number of case that had symptom after intervention] Urine output [Timeframe 24 hour after cesarean section urine volume in urine bag /on foley catheter] INCLUSION CRITERIA: 1. At least 18 years old 2. singleton term uncomplicated pregnancy (37‐42 weeks) 3. indication for cesarean section 4. regional anesthesia (carbetocin is licensed for use with regional anesthesia only)