Antidiabetic and Antioxidant Effects of Methanolic Extracts of Leaf and Seed of Tetracarpidium conophorum on Alloxan-Induced Diabetic Wistar Rats

Abstract

Methanolic extracts of Tetracarpidium conophorum (TCME) leaf, seed or leaf + seed extract demonstrated high capacity for reversing hyperglycemia and oxidative stress comparable with the standard anti-diabetic drug, metformin, in alloxan-induced diabetic rats. The leaf + seed extracts showed the best activity among the extracts and also ameliorated oxidative stress-induced damage of pancreas and liver tissue to normal state.