Antiepileptic drug optimization using ambulatory electrocorticographic data from an implanted brain-responsive neurostimulator

Abstract

Effectiveness of antiepileptic drugs (AEDs) has been traditionally monitored by patient-reported seizures. A 31-year-old male patient was treated with a responsive neurostimulation system (RNS). The ambulatory electrocorticographic data were used to guide AED choice and dosing in achieving subsidence of disabling seizures and minimization of the adverse effects of polypharmacy.