The inhibition of polyisoprenoids from NYPA fruticans leaves on cyclooxygenase 2 expression of widr colon cancer cells

Abstract

Objective: The objective of the study was to investigate the inhibitory activity of polyisoprenoids from Nypa fruticans leaves on the expression of cyclooxygenase 2 (COX-2) against colon cancer cells. Methods: Anticancer activity performed was tested by dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method on colon cancer cell WiDr. The expression of COX-2 was observed by the immunocytochemistry method. Result: Polyisoprenoids fromN. fruticans leaves exhibit anticancer activity onWiDr cells through inhibition of COX-2 expressionwith IC50180.186±7.16 μg/ml. Conclusions: This study showed that polyisoprenoids from N. fruticans leaves promise chemopreventive agents for colon cancer through COX-2 inhibition.