Overview on Biological Activities of Pyrazole Derivatives

Abstract

Pyrazoles are appraised as medicinally significant heterocyclic nuclei that exhibit a widespread spectrum of biological properties. The existence of pyrazole derivatives as pharmacophore in distinct remedial divisions like the antipsychotic CDPPB, an effective anti-inflammatory, celecoxib; difenamizole, an analgesic, rimonabant; the anti-obesity drug, the antidepressant agent fezolamide and betazole, a H2-receptor agonist have ascertained medicinal potentiality of this scaffold. In this regard, pyrazole, one of the most powerful pharmacophores, has been an important topic of research for the scientist around the globe. This chapter draws special attention to the various pharmacological and biological potentiality as well several studies on the pharmacological potency of pyrazole scaffolds emerged by various research groups all over the world are described.