Retinal Sensitivity and Fixation Stability Changes during Repeated Microperimetry

Abstract

Purpose: To determine and compare the intersession test-retest variability of different microperimetric parameters in healthy volunteers and age-related macular degeneration (AMD) patients by MAIA microperimetry. Methods: Twenty-four eyes of 12 healthy volunteers and 22 eyes of 11 AMD patients were included in this study. Microperimetry examinations were performed three times on each eye of all participants by MAIA microperimetry (CenterVue, Padova, Italy). The second measurement was performed on the same day and the third measurement one week after the first test. Retinal light sensitivity, stability of fixation, and macular integrity were recorded. Statistical analysis was performed by Microsoft Excel software and StatSoft Statistica software. Results: During the examinations, the average threshold had not changed significantly (p>0.475) in time in healthy and AMD patients. Fixation stability was relatively constant (nearly 100%) in healthy subjects as compared to the increase in the improving eye condition of AMD patients (p=0.042). Macular integrity was stable in both groups during the examinations. Conclusion: A learning effect was found in fixation stability of AMD patients by MAIA microperimetry. The improvement in fixation stability might be considered, especially prior to biofeedback training protocols in AMD patients.