Choroidal metastasis in advanced adenosquamous endometrial cancer

Abstract

Endometrial cancer is one of the main gynecological neoplasm, occupying the ninth place in incidence worldwide. The adenosquamous histological subtype is very rare, approximately 5% of all endometrial neoplasms. Choroidal metastases have an overall incidence of 2 to 7%, are extremely rare in endometrial cancer; in the literature are reported associated with breast, liver and lung cancer, and gastrointestinal neoplasms. There are only case reports of choroidal metastases associated with endometrial cancer histologic-seroso-papillary subtype and adenocarcinoma, associated with immunosuppression. We present the case of 38 years-old woman, referred to the ISSEMyM State Cancer Center, Toluca, State of Mexico, due to abnormal transvaginal haemorrhage, chronic pelvic pain and weight loss. Study protocol was started, concluding adenosquamous endometrial neoplasm FIGO stage IVB, with lung tumor activity data, lytic destruction of the pubic symphysis, and bone and retroperitoneal activity. Treatment with palliative radiotherapy was initiated, followed by pivotal chemotherapy with cisplatin and driamycin. Subsequently, progression of the disease to the central nervous system is documented, providing radiotherapy all the skull and then to left-sided choroid operated with palliative radiotherapy, with no possibility of evaluating response to treatment of choroidal metastases due to the death of the patient 11 days after the completion of management.