The molecular epidemiology of 66 NDM-producing isolates from 2 Pakistani hospitals was investigated, with their genetic relatedness determined using repetitive sequence-based PCR (Rep-PCR). PCR-based replicon typing and screening for antibiotic resistance genes encoding carbapenemases, other β-lactamases, and 16S methylases were also performed. Rep-PCR suggested a clonal spread of Enterobacter cloacae and Escherichia coli. A number of plasmid replicon types were identified, with the incompatibility A/C group (IncA/C) being the most common (78%). 16S methylase-encoding genes were coharbored in 81% of NDM-producing Enterobacteriaceae. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
CITATION STYLE
Sartor, A. L., Raza, M. W., Abbasi, S. A., Day, K. M., Perry, J. D., Paterson, D. L., & Sidjabat, H. E. (2014). Molecular epidemiology of NDM-1-producing Enterobacteriaceae and Acinetobacter baumannii isolates from Pakistan. Antimicrobial Agents and Chemotherapy, 58(9), 5589–5593. https://doi.org/10.1128/AAC.02425-14
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