The relationship of total body composition with bone mineral density in postmenopausal women with type 2 diabetes

Abstract

Aim: To determine the relationship between bone mineral density (BMD) and total body composition in postmenopausal women with type 2 diabetes. Materials and Methods: The study included 78 women, from 50 to 70 years of age (median 63 years). Twenty women had normal body mass index (BMI), 29 ones were overweight and 29 had obesity. The body composition and BMD was studied by dual-energy X-ray absorptiometry. Results: Women with normal BMD had higher BMI, total and truncal fat mass, as well lean mass as compared to women with osteoporosis and osteopenia (all p <0.05). Patients with osteoporosis had a lower fat mass at the hips, compared with those with normal BMD. Total and truncal fat mass, as well as lean mass were positively correlated with BMD in the lumbar spine and proximal femur, femoral neck and radius. In multivariate regression analysis fat mass was an independent predictor for total BMD, after adjusting for age, BMI, duration of menopause, HbA1c, glomerular filtration rate and other total body composition parameters. Conclusions: In postmenopausal type 2 diabetic women BMI and fat mass is associated positively with BMD.