Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases. © 2014 Springer Science+Business Media, New York.
CITATION STYLE
Englund, E. A., Zhang, N., & Appella, D. H. (2014). Cyclopentane peptide nucleic acids. Methods in Molecular Biology, 1050, 13–18. https://doi.org/10.1007/978-1-62703-553-8_2
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