Zebrafish in drug discovery: Safety assessment

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Abstract

Included in this review are a series of the more common larval and adult zebrafish safety screens that have been developed over the past decade. As such, this is not a comprehensive list but aims to highlight benefits, advances, and pitfalls of key screens related solely to the cardiovascular system and CNS, as well as provide comparisons to earlier models and alternative in vitro and in vivo screens.

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Hill, A. (2013). Zebrafish in drug discovery: Safety assessment. In Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Second Edition (pp. 605–630). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_22

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