Cytotoxic Triterpenes from a Chinese Medicine, Goreishi

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Abstract

Bioactivity-guided fractionation of the methanol extract of Goreishi (the feces of Trogopterus xanthipes milne-edwards) afforded one new and three known cytotoxic triterpenes, namely, 3-0-cis-p-coumaroyltormentic acid, pomolic acid, 2α-hydroxyursolic acid, and jacoumaric acid. In the course of this investigation, six additional compounds having no cytotoxic activity were isolated, namely, maslinic acid, 3-0-trans-p-coumaroylmaslinic acid, ursolic acid, tormentic acid, euscaphic acid, and a new triterpene, 3-0-trans-p-coumaroyltormentic acid. The structures of the new compounds were established on the basis of X-nucIeus-proton correlation with fixed evolution time (XCORFE) and other spectroscopic evidence. © 1989, The Pharmaceutical Society of Japan. All rights reserved.

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Numata, A., Yang, P., Takahashi, C., Fujiki, R., Nabae, M., & Fujita, E. (1989). Cytotoxic Triterpenes from a Chinese Medicine, Goreishi. Chemical and Pharmaceutical Bulletin, 37(3), 648–651. https://doi.org/10.1248/cpb.37.648

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