The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy on this subtype is still an unresolved issue. Nineteen patients with localized signet ring cell adenocarcinomas received taxane-based regimens, and 17 patients underwent surgery. Complete resection was achieved in 80 %, and median overall survival was 40.8 months (95 % confidence interval (CI), 20.2 - not reached). Even though one patient achieved a complete pathological response, seven patients had an upstaging of their tumors at surgery. The potential benefits of taxane-based chemotherapy seem to be limited to a reduced number of patients.
CITATION STYLE
Kim, S., Fiteni, F., Paget-Bailly, S., Ghiringhelli, F., Lakkis, Z., Jary, M., … Borg, C. (2015). The impact of taxane-based preoperative chemotherapy in gastroesophageal signet ring cell adenocarcinomas. Journal of Hematology and Oncology, 8(1). https://doi.org/10.1186/s13045-015-0148-y
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