Biomarkers of Extracellular Matrix Remodeling in Liver Diseases

Abstract

The common denominator, regardless of the underlying etiology, of chronic liver diseases is liver fibrosis. The hallmark of fibrosis is the accelerated accumulation of extracellular matrix proteins, ultimately leading to loss of organ function. The extracellular matrix consists of fibrous and nonfibrous macromolecules such as collagens, elastin, and proteoglycans.