Collective Dynamics of Neural Networks With Sleep-Related Biological Drives in Drosophila

Abstract

The collective electrophysiological dynamics of the brain as a result of sleep-related biological drives in Drosophila are investigated in this paper. Based on the Huber-Braun thermoreceptor model, the conductance-based neurons model is extended to a coupled neural network to analyze the local field potential (LFP). The LFP is calculated by using two different metrics: the mean value and the distance-dependent LFP. The distribution of neurons around the electrodes is assumed to have a circular or grid distribution on a two-dimensional plane. Regardless of which method is used, qualitatively similar results are obtained that are roughly consistent with the experimental data. During wake, the LFP has an irregular or a regular spike. However, the LFP becomes regular bursting during sleep. To further analyze the results, wavelet analysis and raster plots are used to examine how the LFP frequencies changed. The synchronization of neurons under different network structures is also studied. The results demonstrate that there are obvious oscillations at approximately 8 Hz during sleep that are absent during wake. Different time series of the LFP can be obtained under different network structures and the density of the network will also affect the magnitude of the potential. As the number of coupled neurons increases, the neural network becomes easier to synchronize, but the sleep and wake time described by the LFP spectrogram do not change. Moreover, the parameters that affect the durations of sleep and wake are analyzed.