Protein degradation by the proteasome is one of the key steps in cell biology and in immune biology. For degradation a mathematical model can be based on a binomial distribution, where the wanted cleavage probabilities are characterized by a minimization problem. The proposed method analyzes the singular values of the Jacobian, thus giving a significant parameter reduction. The computation time is 50 fold reduced compared to the unreduced model, which in practice means hours instead of days for a run. The implementation is based on MATLAB. © 2008 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Stolte, T., & Rentrop, P. (2008). A singular value based probability algorithm for protein cleavage. In From Nano to Space: Applied Mathematics Inspired by Roland Bulirsch (pp. 99–110). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-74238-8_9
Mendeley helps you to discover research relevant for your work.