Sex differences in long-term clinical outcomes of acute myocardial infarction according to the presence of diabetes mellitus

Abstract

Background/Aims: This study compared long-term clinical outcomes between male and female acute myocardial infarction (AMI) patients with and without diabetes mellitus (DM). Methods: From November 2011 to December 2015, 13,104 patients with AMI were enrolled in the Korea Acute Myocardial Infarction Registry National Institutes of Health (KAMIR-NIH) (4,458 diabetic patients and 8,646 non-diabetic patients). Propensity score matching (PSM) was used to reduce bias due to confounding variables. Following PSM, 2,046 diabetic patients, 1,023 males (69.8±9.4 years) and 1,023 females (69.9±9.4 years); and 3,412 non-diabetic patients, 1,706 males (70.0±10.4 years) and 1,706 females (70.4±10.8 years) were analyzed. Clinical outcomes were compared between male and female patients with and without diabetes over a 3-year clinical follow-up. Results: In diabetic patients, mortality (21.1% vs. 21.5%, p=0.813) and major adverse cardiac events (MACE) (30.6% vs. 31.4%, p=0.698) were not significantly different between males and females. However, mortality (15.8% vs. 12.0%, p=0.002) and MACE (20.8% vs. 15.6%, p<0.001) were significantly higher in male non-diabetic patients than in female non-diabetic patients. The predictors of mortality for both males and females in the diabetic and non-diabetic groups were old age, heart failure, renal dysfunction, anemia, and no percutaneous coronary intervention. Conclusions: The long-term clinical outcomes in AMI patients with DM did not significantly differ by sex. However, the mortality and MACE in non-diabetic male patients were higher than those in females.