LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma

15Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.
Get full text

Abstract

High levels of microvessel density (MVD) indicate poor prognosis in patients with malignant glioma. Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3, a potential tumor suppressor, plays an important role in tumor progression and may serve as a biomarker in many human cancers. However, its role and underlying mechanism of action in glioma angiogenesis remain unclear. In the present study, we used loss- and gain-of-function assays to show that LRIG3 significantly suppressed glioma-induced angiogenesis, both in vitro and in vivo. Mechanistically, LRIG3 inhibited activation of the PI3K/AKT signaling pathway, downregulating vascular endothelial growth factor A (VEGFA) in glioma cells, thereby inhibiting angiogenesis. Notably, LRIG3 had a significant negative correlation with VEGFA expression in glioma tissues. Taken together, our results suggest that LRIG3 is a novel regulator of glioma angiogenesis and may be a promising option for developing anti-angiogenic therapy.

References Powered by Scopus

Global cancer statistics, 2012

25520Citations
N/AReaders
Get full text
9176Citations
1450Readers
Get full text

Malignant gliomas in adults

3517Citations
1156Readers
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Peng, C., Chen, H., Li, Y., Yang, H., Qin, P., Ma, B., … Guo, D. (2021). LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma. Frontiers in Oncology, 11. https://doi.org/10.3389/fonc.2021.621154

Readers over time

‘21‘22‘2401234

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

67%

Professor / Associate Prof. 1

33%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 4

80%

Medicine and Dentistry 1

20%

Save time finding and organizing research with Mendeley

Sign up for free
0