Newer developments in the conformational analysis of carbohydrates

Abstract

The lecture is mainly concerned with research from the author’s laboratory on substitutional and solvation effects on conformational equilibria as estimated from NMR and optical rotation data. Reference is made to the use of empirical rules of rotation for estimating conformational preferences and to how x-ray crystallographic data on the torsional angles defined by vicinal atoms may become of importance to both the interpretation of rotation and NMR data. The anomeric and reverse anomeric effects on glycoside conformation are considered and reference is made to solvation effects on the interaction between oxygen atoms in gauche and in syn-axial relationships. Effects of solvation on the orientation of the hydroxymethyl group of hexopyranoses and on intramolecular hydrogen bonding are presented. © 1971, Walter de Gruyter. All rights reserved.