The computational analysis of protein – Ligand Docking with diverse genetic algorithm parameters

Abstract

The binding energy is the significant factor which elucidates the efficiency of docking between protein-ligand and protein-protein. To perform the Docking process, Genetic algorithm with its standard parameters is been used very often which will furnish the docking conformations, binding energies, interactions etc. In this proposed work, the parameters of genetic algorithm are variably changed for the docking process and we have observed the enhancement of binding energy, number of interactions etc. which plays a substantial role in the drug design.