Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages

Abstract

Background: ADAM17 mediates shedding of CD163 and tumor necrosis factor-α (TNF-α) during inflammation. Results: Similar substrate sequence motifs in proTNF-α and CD163 are essential for ADAM17-mediated cleavage. Conclusion: The structural basis for shedding of CD163 and TNF-α is disclosed. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.