Further statistical analysis for genome-wide expression evolution in primate brain/liver/fibroblast tissues.

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Abstract

In spite of only a 1-2 per cent genomic DNA sequence difference, humans and chimpanzees differ considerably in behaviour and cognition. Affymetrix microarray technology provides a novel approach to addressing a long-term debate on whether the difference between humans and chimpanzees results from the alteration of gene expressions. Here, we used several statistical methods (distance method, two-sample t-tests, regularised t-tests, ANOVA and bootstrapping) to detect the differential expression pattern between humans and great apes. Our analysis shows that the pattern we observed before is robust against various statistical methods; that is, the pronounced expression changes occurred on the human lineage after the split from chimpanzees, and that the dramatic brain expression alterations in humans may be mainly driven by a set of genes with increased expression (up-regulated) rather than decreased expression (down-regulated).

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Gu, J., & Gu, X. (2004). Further statistical analysis for genome-wide expression evolution in primate brain/liver/fibroblast tissues. Human Genomics, 1(4), 247–254. https://doi.org/10.1186/1479-7364-1-4-247

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