Antidiabetic and Antilipidemic Effect of Aloe barbadensis Gel Extract in Alloxan Induced Diabetic Mice

Abstract

Aloe barbadensis is known for its antidiabetic and antihyperlipidemic activity, this study was aimed to check efficacy and toxic limits of different doses of gel extract in diabetic induced albino mice. Male albino mice, weighing (25±5g) were divided into three groups; Group 1: normal (non diabetic nontreated), Group 2: diabetic non treated (DNT), Group 3: diabetic treated (DT) mice. Group 3 was treated with three doses of A. barbadensis (200 mg/ kg, 300 mg/kg and 400 mg/kg) per day for 14 days were assigned as DT1, DT2 and DT3 respectively. Aloe vera given orally produced significantly decline in the serum biochemical parameters viz. total cholesterol, triacylglycerols and glucose in Group 3 in comparison to Group 1 (p<0.05). An overall statistically significant decline in serum values of studied parameters was noted compared to the corresponding control values. High dose (400mg/kg) was effective in reducing blood sugar random and fasting blood glucose level (58.00±6.35 and 66.00±2.5 mg/ dl) respectively. High dose was effective in reducing bilirubin (0.67±0.15), SGPT (35.67±2.03), SGOT (127.67±4.67) and alkaline phosphatase (86.33±1.86) compared to their corresponding control group values. A. barbadensis (400mg/kg) reduced cholesterol (78.00±2.08), triglycerides (83.67±3.28), HDL cholesterol (49.33.67±2.33) and LDL cholesterol (61.67±3.84). Pancreatic and hepatic sections from diabetic induced group 2 mice showed vacuolization and inflammation of cells whereas, group 3 showed improvements with normal islets with surrounding acini and lobular structure of hepatocytes.