The membrane potential is an essential parameter of a living cell. However, measurements of the membrane potential using conventional techniques are associated with a number of artifacts. Cell-attached recordings of the currents through NMDA receptor channels enable noninvasive measurements of the neuronal membrane potential. This approach overcomes the problem of a leak conductance introduced during intracellular sharp electrode recordings and whole-cell patch-clamp recordings. Here, we describe the procedures of using cell-attached recordings of NMDA receptor channels to measure the true membrane potential.
CITATION STYLE
Khazipov, R. (2017). NMDA receptors as voltage sensors. In Methods in Molecular Biology (Vol. 1677, pp. 283–290). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7321-7_16
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