Abstract
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody- dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
Author supplied keywords
Cite
CITATION STYLE
Castanha, P. M. S., Nascimento, E. J. M., Braga, C., Cordeiro, M. T., De Carvalho, O. V., De Mendonça, L. R., … Marques, E. T. A. (2017). Dengue virus-specific antibodies enhance Brazilian Zika virus infection. Journal of Infectious Diseases, 215(5), 781–785. https://doi.org/10.1093/infdis/jiw638
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
