Haplotype in ABCC4 gene by PCR-SSCP technique in Iraqi Asthmatic patients

Abstract

The current study was carried out to discover the relation of ABCC4(rs1751034) haplotypes polymorphisms with asthma in Iraqi patients, this SNIP was located on exon 19 and PCR-SSCP technique dealed in this study, whole blood was processed to DNA extraction. this study includes about 165 subjects (female and male) categorized in to two groups, the first group includes 86 patients suffered from asthma and the second group includes 50 apparently healthy subject as control group. the data show that there was strong association between ABCC4(rs1751034 ) and asthma in one haplotype from three (p<0.05). This study revealed that there was a link between ABCC4 polymorphisms with asthma, our finding required more work up to use this polymorphism as early suggestion of this disease.