Protection against β adrenoceptor agonist reduction of plasma potassium in severe but not in moderate hypokalemia

Abstract

K-depleted and control rats were anesthetized and infused with terbutalin. In controls, plasma K concentration (pK) decreased by 0.7mm (P=0.01). In moderate hypokalemia terbutalin-induced decrease in pK was reduced by 0.3mm for each 1mm decrease in pK (n=8, R 2=0.82, P=0.002) and by 0.2mm for each 10mmol/g wet wt. decrease in muscle K content (n=8, R 2=0.66, P=0.01). Hence, for baseline pK of 4, 3 and 2mm, decrease in pK was 0.7, 0.4 and 0.1mm, respectively. In severe hypokalemia (1.7mm), terbutain induced no further reduction in pK. The combined infusion of insulin and terbutalin showed no additive effect. Normalization of pK by KCl infusion in severe hypokalemia immediately abolished protection against terbutalin induced further pK reduction. Hence, terbutalin clamped pK at around 4mm, whereas it continued to increase to around 5mm without terbutalin infusion. Major new findings are: Protection against terbutalin induced further reduction in pK in severe pre-existing hypokalemia (<2mm) and blunted but nevertheless severe further reduction in pK in more moderate pre-existing hypokalemia; immediate abolishment of protection by normalization of pK; protection against additive reduction in pK by terbutalin and insulin in severe hypokalemia. It may be advisable to avoid hypokalemia when using β adrenoceptor agonists and to maintain pK in the upper normal range if at the risk of arrhythmia. © 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique.