A constitutive activation of the Wnt/β-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway.
CITATION STYLE
Grimaldi, M., Boulahtouf, A., Prévostel, C., Thierry, A., Balaguer, P., & Blache, P. (2018). A cell model suitable for a high-throughput screening of inhibitors of the Wnt/β-catenin pathway. Frontiers in Pharmacology, 9(OCT). https://doi.org/10.3389/fphar.2018.01160
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