Quantitative Structure-activity Relationships in Minor Tranquilizers Benzodiazepinooxazole Derivatives

Abstract

Quantitative structure-activity relationships (QSAR) for benzodiazepinooxazoles were formulated in 9 equations correlating chemical structure with 9 types of biological activities. The equations describing the relationships are log l/C=aπ-7+bF-3 + c.F-4+ dI-1+eI-2-+ fI-3+g where C is the molar concentration causing 50% biological activity, π-7 is the hydrophobic constant for substituents on the N7 position of 1,4-diazepine (II), F-3 and F-4 refer to the electronic effects of R3 and R4, respectively, and the indicator variable I-1, I-2 and 1–3 refer to the methyl function of the R8, R9 and R10, respectively. © 1977, The Pharmaceutical Society of Japan. All rights reserved.