The pediatric management of klinefelter syndrome: What to do and when from infancy to puberty

Abstract

The clinical picture of Klinefelter syndrome is extremely variable, in fact the characteristic phenotype of the hypogonadal eunuchoid boy is less frequent than his normal appearance. In pediatric age the clinical signs, useful for diagnosis, are even more rare and non-specific. If the abnormalities of sexual and/or psychomotor development are detected early, it’s possible to set up a clinical follow-up to prevent or intercept promptly the disorders related to the condition. In fact, it is the pediatrician’s job to know the health issues of the adult SK patients and identify their warning signs in the pediatric age, distinguishing specialistic problems from the pediatric ones.