Viral loads in clinical specimens and SARS manifestations

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Abstract

A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness, Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with 'abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.

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Hung, I. F. N., Cheng, V. C. C., Wu, A. K. L., Tang, B. S. F., Chan, K. H., Chu, C. M., … Yuen, K. Y. (2004). Viral loads in clinical specimens and SARS manifestations. Emerging Infectious Diseases, 10(9), 1550–1557. https://doi.org/10.3201/eid1009.040058

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