Resistance to Trypanosoma crvzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-α, IFN-γ and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-γ and TNF-α in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed.
CITATION STYLE
Abrahamsohn, I. A. (1998). Cytokines in innate and acquired immunity to Trypanosoma cruzi infection. Brazilian Journal of Medical and Biological Research, 31(1), 117–121. https://doi.org/10.1590/S0100-879X1998000100015
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