Incidence of Sub-Clinical Prostatic Disease at Autopsy in the University College Hospital, Ibadan

Abstract

This prospective study was undertaken to ascertain theincidence, histology and pathological features of different types ofasymptomatic or sub clinical prostatic diseases. Prostate glandswere obtained from 79 consecutive adult males aged 30 years and above who diedfrom non-prostate related diseases at the University College Hospital Ibadanover an eighteen months period. The glands were weighed and fixed in 10% neutral bufferedformalin. The sampling method of the prostate gland described by Vainer et al. (2011) was employed in this study. Paraffin-embedded sections werestained with haematoxylin and eosin and were systematically examined for focalprostate disease. The patients’ ages ranged from 30 to 86 years. The most commonlesions were nodular hyperplasia (81%), followed by adenocarcinoma (6.3%).Three cases (3.8%) had schistosomiasis. Adenocarcinoma and nodular hyperplasiaoccurred in relatively older patients than those with normal glands or chronicprostatitis/schistosomiasis (p = 0.05). There was an increase in weight of theprostate with age (p The low frequency of prostatic adenocarcinomaand the absence of high grade prostatic intraepithelial neoplasia in this studydespite the observation of increasing number of prostatic carcinoma required furtherinvestigation. Schistosomiasis was also found to be present in the adult malepopulation.