Intestinal fatty acid-binding protein and acute gastrointestinal injury grade in postoperative cardiac surgery patients

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Abstract

Background and Aim: Gastrointestinal complications post cardiac surgery are infrequent but difficult to diagnose and carry a high mortality. Plasma intestinal fatty acid-binding protein (I-FABP) concentrations and the relationship between I-FABP, gastrointestinal dysfunction, and postoperative outcomes were investigated in patients who developed gastrointestinal dysfunction (acute gastrointestinal injury [AGI] grade ≥2) and those with normal gastrointestinal function. Methods: Patients with (AGI 2 group, n = 11) and without (matched controls, AGI 0 group, n = 22) early postoperative gastrointestinal dysfunction were extracted from a larger single-center prospective observational study, including adults undergoing elective cardiac surgery with extracorporeal circulation, and investigated in this nested case-control analysis. Results: Both groups displayed variations in I-FABP concentrations with higher I-FABP on postoperative Day 1 compared to baseline and postoperative Days 2 and 3 (p

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Seilitz, J., Edström, M., Kasim, A., Jansson, K., Axelsson, B., & Nilsson, K. F. (2021). Intestinal fatty acid-binding protein and acute gastrointestinal injury grade in postoperative cardiac surgery patients. Journal of Cardiac Surgery, 36(6), 1850–1857. https://doi.org/10.1111/jocs.15430

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