The Effects of Ethanol Extract of Asian Pigeon Wings (Clitoria ternatea L.) Flower on Body Weight and Malondialdehyde Level in Diabetes Rat Model

Abstract

Diabetes mellitus. is ai global metabolici disease with high morbidity and imortality rates. Many diabetes patients have difficulties lowering their blood glucose levels although they are taking anti-diabetes drugs. Flower of Asian pigeon wings (Clitoria ternatea L) contains flavonoid, anthocyanin, compounds and possess high antioxidant activity, which can lower postprandial glucose levels in Albino rats with diabetes. The purpose of this study was to analyze the "effect-of ethanol extract of Asian pigeon wings flower on body weight (BW) and malondi-aldehyde (MDA) level of diabetes rats. Male-wistar rats-aged 8-12 weeks old and weighed 150-200 g were used in this experimental study. Rats were induced with 45 mg/kg BW streptozotocin and 110 mg/kgBW nicotinamide to generate type 2 diabetes. Diabetes rats were randomly divided into two groups:-the T1 group was giveni1.8 mg/kg BW acarbose and the T2 group was given 150 mg/kgBW. Extract of Asian pigeon wings flower for 21 days. Collected data before, during and after treatment were analyzed using the repeated measure ANOVA. The mean rat BW at days 14 th and 21 st of T1 (189 ± 4.17 and 196 ± 3.65 g) was higher than the mean rat BW of T2 (184 ± 5.81 and 189 ± 6.15 g). Increased rat BW in both groups was significantly higher than that of day 1 (180 ± 3.84 and 179 ± 6.22 g respectively). The mean MDA levels of T1 significantly reduced from 9,45 ± 0,31 µmol/l at day 1 to 3.59 ± 0,22 µmol/l at day 14 and 3.00 ± 0.23 µmol/l at day 21 with p = 0.001. The T2 group also had significant reductions of mean MDA levels from 9,56 ± 0.18 µmol/l at day 1 to 5.45 ± 0.26 µmol/l a day 14 and 4.80 ± 0.25 µmol/l at day 21 with p = 0,001. In conclusion, administration of 150 mg/kg BW extract of Asian pigeonwings flower is able to increase BW and reduce MDA level of diabetes rats but its metabolic and anti-oxidant activities are lower than the acarbose drug.