Synthesis, spectral and antimicrobial studies of bis(cyclopentadienyl) titanium(IV) derivatives with Schiff bases derived from 2-amino-5-phenyl-1,3,4- thiadiazole

Abstract

The reactions of bis(cyclopentadienyl)titanium(IV) dichloride with Schiff bases derived by condensing 2-amino-5-phenyl-1,3,4-thiadiazole with benzaldehyde (SPT), 4-nitrobenzaldehyde (SNT), 4-methoxybenzaldehyde (SMT), 2-hydroxybenzaldehyde (SSTH) or 2-hydroxyacetophenone (SATH) havebeen studied in refluxing tetrahydrofuran and complexes of types [Cp2TiCl(SB)]Cl (SB= SPT, SNT or SMT)and [Cp2Ti(SB')]Cl (SB'H= SSTH or SATH) have been isolated. Tentative structural conclusions are drawnfor these reaction products based upon elemental analyses, electrical conductance, magnetic moment andspectral (UV-vis, IR and 1H NMR) data. Studies were conducted to assess the growth-inhibiting potential ofthe complexes synthesized, and the ligands, against various fungal and bacterial strains.