Molecular subtypes are frequently discordant between lesions in patients with synchronous colorectal cancer: Molecular analysis of 59 patients

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Abstract

Background: We aimed to investigate the molecular features of synchronous colorectal cancer (CRC). Materials and Methods: Out of 1,262 patients with CRC, 130 lesions in 59 patients with synchronous CRC were retrospectively analyzed. Microsatellite, v-Ki-Ras2 Kristen rat sarcoma viral oncogene homolog (KRAS), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), tumor protein 53 (TP53) and β-catenin status were evaluated and compared between synchronous CRC lesions in each patient. Results: The subtypes of instability, BRAF and β-catenin subtypes was significant but low. Patients with discordant KRAS and TP53 were not concordant between lesions in the same patient, and concordance of microsatellite KRAS/BRAF subtypes comprised 50.8% of those with synchronous CRC. The rate of patients with lesions containing both mutL homolog 1 (MLH1) methylation and microsatellite stable status was 66.7% in those with synchronous CRC, with at least one lesion with high microsatellite instability. Conclusion: The present study on synchronous CRC demonstrated a low concordance of molecular subtypes between lesions in the same patient. A molecular analysis of metastatic lesions is warranted for molecular targeted therapy of metastatic synchronous CRC.

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Arakawa, K., Hata, K., Nozawa, H., Kawai, K., Tanaka, T., Nishikawa, T., … Ishihara, S. (2019). Molecular subtypes are frequently discordant between lesions in patients with synchronous colorectal cancer: Molecular analysis of 59 patients. Anticancer Research, 39(3), 1425–1432. https://doi.org/10.21873/anticanres.13258

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