Hepatocellular carcinoma in a long‐term survivor of acute lymphocytic leukemia

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Abstract

Hepatocellular carcinoma (HCC) occurred in a 28‐year‐old woman treated for acute lymphocytic leukemia (ALL) with methotrexate (MTX) and 6‐mercaptopurine (6‐MP), off all therapy for 15 years, who was also heterozygous for alpha‐1 antitrypsin (α‐1 AT) deficiency. MTX is responsible for the development of HCC in this patient. The literature concerning the incidence of HCC in patients treated with MTX and 6‐MP and in α‐1 antitrypsin deficiencies is reviewed. Copyright © 1987 American Cancer Society

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Fried, M., Kalra, J., Ilardi, C. F., & Sawitsky, A. (1987). Hepatocellular carcinoma in a long‐term survivor of acute lymphocytic leukemia. Cancer, 60(10), 2548–2552. https://doi.org/10.1002/1097-0142(19871115)60:10<2548::AID-CNCR2820601033>3.0.CO;2-H

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