Significant relationship of visual field sensitivity in central 108 to thickness of retinal layers in retinitis pigmentosa

Abstract

PURPOSE. To determine the relationship between the sensitivity of the retina in the central 108 and the thickness of the retinal layers in patients with retinitis pigmentosa (RP). METHODS. Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and spectral-domain optical coherence tomography (SD-OCT). The thicknesses of the photoreceptor outer segment (OS), outer nuclear layer (ONL), inner nuclear layer (INL), and the retinal nerve fiber layer (RNFL) were measured at 1°, 3°, 5°, 7°, and 9° from the fovea. The same measurements were made on the SD-OCT images of 40 healthy subjects and used as controls. The relationships between the retinal sensitivities and retinal layer thicknesses were determined. RESULTS. The thicknesses of the OS and ONL and their product were significantly and positively correlated with the retinal sensitivities. The thickness of the INL was significantly and negatively correlated with the sensitivity. The strongest correlation with the sensitivity was with the OS thickness (marginal R 2 [mR 2 ] = 0.525, P < 0.001), followed by the product of the OS and ONL thicknesses (mR 2 = 0.420, P < 0.001), ONL thickness (mR 2 = 0.416, P < 0.001), and the INL thickness (mR 2 = 0.014, P = 0.044). The thickness of the RNFL was not correlated with the sensitivity (mR 2 = 0.005, P = 0.331). CONCLUSIONS. In contrast to previous reports, the thickness of the OS reflected the retinal sensitivity better than the product of OS and ONL.