Phenotypic evolution through variation in splicing of the noncoding RNA COOLAIR

75Citations
Citations of this article
113Readers
Mendeley users who have this article in their library.

Abstract

The extent to which natural polymorphisms in noncoding sequences have functional consequences is still unknown. A large proportion of the natural variation in flowering in Arabidopsis thaliana accessions is due to noncoding cis polymorphisms that define distinct haplotypes of FLOWERING LOCUS C (FLC). Here, we show that a single natural intronic polymorphism in one haplotype affects FLC expression and thus flowering by specifically changing splicing of the FLC antisense transcript COOLAIR. Altered antisense splicing increases FLC expression via a cotranscriptional mechanism involving capping of the FLC nascent transcript. Single noncoding polymorphisms can therefore be a major contributor to phenotypic evolution through modulation of noncoding transcripts.

References Powered by Scopus

Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering time

829Citations
N/AReaders
Get full text

Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target

723Citations
N/AReaders
Get full text

Coupling mRNA processing with transcription in time and space

593Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Long non-coding RNAs: definitions, functions, challenges and recommendations

849Citations
N/AReaders
Get full text

The FLC locus: A platform for discoveries in epigenetics and adaptation

241Citations
N/AReaders
Get full text

A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

188Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Li, P., Tao, Z., & Dean, C. (2015). Phenotypic evolution through variation in splicing of the noncoding RNA COOLAIR. Genes and Development, 29(7), 696–701. https://doi.org/10.1101/gad.258814.115

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 38

49%

Researcher 30

39%

Professor / Associate Prof. 8

10%

Lecturer / Post doc 1

1%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 68

72%

Biochemistry, Genetics and Molecular Bi... 27

28%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free