Synthesis of (5,6 & 6,6)-oxa-oxa annulated sugars as glycosidase inhibitors from 2-formyl galactal using iodocyclization as a key step

Abstract

Oxa-oxa (5,6 & 6,6) annulated sugars were synthesized from 2-formyl galactal using iodocyclization as a key step. The glycosidase inhibitory activities of the synthesized molecules were tested against commercially available enzymes which showed that the sugar-furan molecules are potent and selective inhibitors.